Monte Sereno is a city in Santa Clara County, California, United States. The population was 3,479 at the 2020 census. The city is located in the foothills of the Santa Cruz Mountains, about 10 miles southwest of San Jose, and is bordered by the town of Los Gatos to the north, east, and south, the Santa Cruz Mountains to the southwest, and the city of Saratoga to the northwest. From Wikipedia