49ers Lose Christian McCaffrey and Jordan Mason to Injuries, Shaking Playoff Hopes

Star running back Christian McCaffrey is out with a knee injury, while backup Jordan Mason also lands on IR, leaving the 49ers' backfield depleted.

Christian McCaffrey suffered a PCL injury during Sunday’s loss to the Buffalo Bills and is expected to miss at least six weeks, effectively ending his season.
Backup running back Jordan Mason sustained a high ankle sprain in the same game and has been placed on injured reserve, sidelining him for at least four weeks.
The 49ers, now 5-7 and last in the NFC West, face long odds of making the playoffs after losing two key offensive players and enduring a three-game losing streak.
Rookie Isaac Guerendo is set to take over as the starting running back, with Patrick Taylor Jr. being promoted from the practice squad to provide depth.
McCaffrey, who missed the first eight games of the season due to Achilles tendinitis, had played only four games this year after an award-winning 2023 season.