Advanced Mapping of GPCR Interactions Revolutionizes Drug Discovery

New technique enables high-throughput analysis of GPCR-RAMP complexes, unveiling extensive therapeutic potential.

• Scientists developed a multiplexed suspension bead array immunoassay to study GPCR-RAMP interactions.
• The method allows simultaneous screening of hundreds of GPCR-RAMP complexes, revealing 122 significant interactions.
• The findings increase known GPCR-RAMP interactions by an order of magnitude, aiding in selective therapeutic design.
• Publicly available resources now include libraries of anti-GPCR antibodies and engineered GPCR genes.
• The research provides insights into why some GPCR-targeting drugs fail and identifies natural ligands for orphan GPCRs.

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