Overview

• Researchers have developed EPI-Clone, a tool that uses natural DNA methylation patterns as 'barcodes' to trace blood stem cell lineage in humans and mice.
• The study confirms that by age 50, a few dominant stem cell clones begin to overtake blood production, with this trend becoming nearly universal by age 60.
• These dominant clones preferentially produce myeloid cells, which are linked to chronic inflammation and increased risk of age-related diseases like heart disease and leukemia.
• EPI-Clone's ability to map clonal dynamics could enable early detection of unhealthy blood aging, offering a potential biomarker for age-related blood disorders.
• The findings pave the way for exploring therapies to selectively target and remove problematic clones, potentially rejuvenating the blood and immune systems.