Breakthrough in Cancer Research: Circular DNA Drives Tumor Growth

New studies reveal extrachromosomal DNA's role in cancer progression and potential for targeted therapy.

Recent research shows that extrachromosomal DNA (ecDNA) is present in 17.1% of tumors, significantly more than previously believed.
ecDNA contains oncogenes and immune-suppressing genes, contributing to aggressive cancer growth and treatment resistance.
The studies highlight ecDNA's role in cancer metastasis and its association with poorer survival rates in patients.
A new therapeutic approach targeting ecDNA with CHK1 inhibitors is in early-stage clinical trials, showing promise in preclinical studies.
These findings challenge traditional genetic inheritance theories and open new avenues for cancer treatment development.