Christina Applegate Faces Severe MS Symptoms Leading to Over 30 Hospitalizations

The actress continues to advocate for better understanding of MS while preparing for a colonoscopy to investigate potential motility issues linked to her symptoms.

Christina Applegate has been hospitalized more than 30 times in three years due to severe vomiting, diarrhea, and pain related to multiple sclerosis (MS).
She suspects her gastrointestinal symptoms may be linked to motility issues caused by MS, though her neurologist has not confirmed this connection.
Applegate plans to undergo a colonoscopy on March 20, 2025, to further explore the potential cause of her symptoms.
Despite these challenges, she uses her 'MeSsy' podcast, co-hosted with Jamie-Lynn Sigler, to share her experiences and connect with others living with MS.
Applegate's candid discussions about her symptoms highlight the variability of MS and the importance of patient advocacy and transparency.