Overview

• The Intrinsic Capacity Clock quantifies aging through DNA methylation patterns linked to mobility, cognition, mental health, vision, hearing and nutrition.
• The model was trained on INSPIRE-T cohort data and validated against the Framingham Heart Study, outperforming first- and second-generation clocks in predicting all-cause mortality.
• A dried-blood spot assay is in development to enable non-invasive functional aging assessments in low- and middle-income countries.
• The Buck Institute-led team and IHU HealthAge have been named XPRIZE Healthspan semifinalists, using the IC Clock to gauge responses to hybrid interventions combining ketone esters with ICOPE-INTENSE regimens.
• Although the World Health Organization classified intrinsic capacity decline in ICD-11, US FDA approval for aging-targeted treatments remains pending, and the IC Clock could provide the quantifiable endpoints needed to bridge this regulatory gap.