Overview

• Fibromyalgia affects 2–4% of the global population, with a 9:1 female-to-male ratio, and lacks a definitive diagnostic test or cure.
• Recent research highlights neuroinflammation and SGK1-targeting molecules as potential breakthroughs in understanding and treating the condition.
• In Spain, over 275,800 cases are officially diagnosed, but experts estimate nearly one million people may be affected, highlighting significant underdiagnosis.
• Patients report severe impacts on quality of life, including chronic pain, fatigue, depression, and social stigma, often compounded by delayed diagnoses.
• Multimodal treatment approaches combining education, supervised exercise, psychological support, and personalized pharmacological therapies remain the cornerstone of care.