Global Study Identifies 293 New Genetic Variants Linked to Depression

The research, spanning 29 countries, enhances understanding of depression's genetic basis and opens pathways for improved treatments.

Researchers analyzed genetic data from over 5 million participants, including 688,808 individuals with depression, in the most diverse study of its kind to date.
A total of 697 genetic variants were linked to depression, with 293 being newly identified, offering fresh insights into the biological underpinnings of the condition.
The study highlights the importance of diversity, with 24% of participants from non-European backgrounds, addressing a major limitation in previous research.
Findings could lead to personalized treatments by targeting specific brain processes and biological pathways associated with depression.
The research reinforces the significant role of genetics in depression while acknowledging the interplay of environmental and lifestyle factors.