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Iran and US Prepare for Fifth Round of Nuclear Talks in Rome

Indirect negotiations, mediated by Oman, continue as Iran's enriched uranium stockpile raises stakes for a potential nuclear deal revival.

Iranians pass by a mural that depicts the two Supreme Leaders of Iran near Enghelab (Revolution) Square in downtown Tehran, Iran on April 8, 2025, four days before the first round of indirect nuclear negotiations with President Trump's administration hosted and mediated by Oman.
FILE - This combo of pictures show President Donald Trump, left, addressing a joint session of Congress at the Capitol in Washington, March 4, 2025, and a handout of Supreme Leader Ayatollah Ali Khamenei attending a ceremony in Tehran, Iran, March 8, 2025. (AP Photo/Ben Curtis - Office of the Iranian Supreme Leader via AP)
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Overview

  • The fifth round of indirect nuclear negotiations between Iran and the US is scheduled to take place in Rome on May 23, 2025.
  • Talks are mediated by Omani Foreign Minister Badr Albusaidi, with delegations communicating through intermediaries rather than direct meetings.
  • The International Atomic Energy Agency (IAEA) has confirmed Iran's uranium stockpile at 274.8 kg enriched to 60% purity, intensifying concerns over nuclear proliferation.
  • The negotiations represent the highest-level engagement between the two nations since the US withdrew from the 2015 Joint Comprehensive Plan of Action (JCPOA) in 2018.
  • Both sides have described previous rounds as constructive, though significant disputes remain over enrichment limits and sanctions relief.