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11mo ago

Maternal Alzheimer's History Linked to Higher Amyloid Levels in Offspring

Study finds distinct parental influences on Alzheimer's risk, with maternal history more strongly associated with amyloid buildup.

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“Some people decide not to pursue a formal diagnosis and attribute memory loss to age, so we focused on a memory loss and dementia phenotype,” Yang said. Credit: Neuroscience News
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Overview

  • Research analyzed 4,400 cognitively unimpaired adults aged 65–85.
  • Maternal history of Alzheimer's linked to increased amyloid levels regardless of symptom onset age.
  • Paternal history only significant if Alzheimer's symptoms appeared early.
  • Amyloid buildup was measured using PET scans in a large clinical trial.
  • Findings suggest maternal inheritance may be crucial for identifying at-risk individuals.