Overview

• A recent study reveals that fasting for at least three days triggers significant changes across multiple organs, indicating a whole-body adaptation to calorie restriction.
• Participants in the study experienced an average weight loss of 5.7 kg, with fat loss being permanent and lean mass loss almost completely reversible after resuming eating.
• The study, involving 12 healthy volunteers on a seven-day water-only fast, identified shifts in around 3,000 proteins, some of which are linked to reduced risks of diseases like rheumatoid arthritis and coronary artery disease.
• Researchers observed a switch from glucose to fat as the body's primary energy source within the first two to three days of fasting.
• The findings could lead to the development of fasting-mimicking treatments for individuals who cannot undergo traditional fasting due to health reasons.