Overview

• Researchers have discovered that 40Hz sensory gamma rhythm stimulation can reduce Alzheimer's disease progression by clearing amyloid proteins via the brain's glymphatic system.
• The treatment involves exposing patients to lights flickering and sounds clicking at a frequency of 40Hz, which has shown cognitive benefits in both mice and early human trials.
• The stimulation increases 40Hz power and synchrony in the brain, which in turn prompts neurons to release peptides that promote amyloid clearance.
• Blocking the function of the aquaporin 4 water channel in astrocyte cells, which facilitates glymphatic fluid exchange, prevented the treatment's beneficial effects on amyloid levels and cognitive functions.
• Further research is needed to fully understand the mechanisms behind this treatment and to determine its long-term effects on human cognition.