NYU Researchers Reveal Gene Activity's Role in Genome Motion

New study finds that active gene transcription influences the dynamic organization of the human genome.

Scientists discovered that transcription-driven motions of genes contribute to the complex movement within the genome.
High-resolution imaging and CRISPR technology were used to visualize and analyze gene motions in live human cells.
Active genes were found to drive genome motion in low-compaction regions, while compacted genomes influenced gene movement regardless of activity.
The research highlights potential implications for understanding diseases linked to gene dysfunction, such as cancer and neurological disorders.
The study provides new insights into the physics of active living systems, offering a deeper understanding of the human genome's organization.