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Oxford Study Reveals Rapid Weight Regain After Stopping GLP-1 Drugs

Patients regain most of their lost weight within 10–20 months of stopping treatment, raising questions about long-term therapy and the need for behavioral support.

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Overview

  • The University of Oxford analysis found patients using older GLP-1 drugs regained their lost weight within 10 months of discontinuation.
  • Newer, high-dose drugs like Wegovy and Mounjaro led to greater initial weight loss but showed substantial regain, with patients typically regaining 10kg within a year and full rebound projected in 18–20 months.
  • The study examined data from 6,370 adults across 11 trials and highlighted that weight regain after stopping GLP-1 drugs is significantly faster than after diets, where weight returns over at least five years.
  • Experts stress that patients discontinuing weight-loss jabs need psychological counseling, behavioral changes, and nutritional support to sustain long-term weight loss.
  • The findings challenge the NHS’s two-year prescription limit, with calls for either lifelong drug use or enhanced post-treatment support to prevent rapid weight rebound.