Study Links Obesity Gene in Dogs and Humans to Appetite Regulation

Cambridge researchers identify genetic similarities between dogs and humans that influence weight gain and appetite control.

Researchers at the University of Cambridge have identified a gene, DENND1B, strongly linked to obesity in both dogs and humans.
The study focused on British Labrador retrievers, finding that dogs carrying the gene had approximately 8% more body fat than those without it.
DENND1B impacts the leptin-melanocortin pathway, a brain mechanism regulating energy balance and appetite, which is also a target for some anti-obesity drugs.
Strict diet and exercise management can prevent obesity in dogs with a high genetic risk, offering parallels to human weight management strategies.
The findings highlight the role of genetics in obesity and suggest dogs are a valuable model for understanding human appetite and weight regulation.