Study Reveals Fat Cells Retain 'Memory' of Obesity, Hindering Long-Term Weight Loss

New research highlights how epigenetic changes in fat cells contribute to the 'yo-yo effect' and challenges in maintaining weight loss after dieting or surgery.

Researchers found that fat cells retain epigenetic markers from obesity, encouraging the body to revert to its prior obese state even after significant weight loss.
This 'obesity memory' alters gene activity, increasing inflammation and reducing normal fat cell function, as observed in both humans and mice.
Experiments showed previously obese mice regained weight faster than control mice when exposed to a high-fat diet, supporting the cellular memory theory.
The study suggests that these epigenetic changes may persist for years, complicating long-term weight management and requiring further research to determine if they are reversible.
Scientists believe this discovery could reduce stigma around obesity and pave the way for new treatments targeting these molecular changes to improve weight loss outcomes.