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Study Reveals Persistent High Mortality in Broken Heart Syndrome, With Men at Greater Risk

Research analyzing 200,000 U.S. cases from 2016 to 2020 shows a steady 6.5% in-hospital death rate, with men facing over twice the mortality of women.

A couple relaxes on Carmel Beach. A new study published in the Journal of the American Heart Association finds that men are more than twice as likely as women to die from takotsubo cardiomyopathy, also known as broken heart syndrome. 
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A couple walks under an umbrella at Pier 39 in San Francisco. A new study published in the Journal of the American Heart Association finds that men are more than twice as likely as women to die from takotsubo cardiomyopathy, also known as broken heart syndrome. 
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Overview

  • The study found that men with broken heart syndrome had an 11.2% in-hospital death rate, more than double the 5.5% rate for women.
  • Overall mortality for the condition remained high at 6.5% from 2016 to 2020, with no significant improvements during the study period.
  • Major complications included congestive heart failure (35.9%), atrial fibrillation (20.7%), cardiogenic shock (6.6%), stroke (5.3%), and cardiac arrest (3.4%).
  • Older adults, particularly those over 61, were most affected, while White adults had the highest incidence rate (0.16%) compared to other racial groups.
  • Experts call for urgent research into tailored treatments and better understanding of sex-based differences in outcomes and risk factors.