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Tufts Engineers Develop Dental Floss That Monitors Stress Through Saliva

The innovative floss uses synthetic polymers to detect cortisol levels and is being prepared for commercialization as a consumer health tool.

Cropped shot of a young couple flossing their teeth together
The saliva is picked up by capillary action through a very narrow channel in the floss. Credit: Neuroscience News

Overview

  • The floss integrates microfluidic channels and synthetic molecularly imprinted polymers (eMIPs) to detect cortisol, a key stress hormone, in saliva.
  • Designed for everyday use, the device collects saliva through the floss string and analyzes it via electrodes in the handle for real-time stress monitoring.
  • The technology demonstrated accuracy on par with leading devices in a study published in ACS Applied Materials & Interfaces in April 2025.
  • Researchers are forming a startup to bring the floss sensor to market, aiming to make stress and health monitoring accessible for routine use.
  • The platform could potentially be adapted to detect other salivary biomarkers like glucose, estrogen, and cancer markers, enabling broader health applications.