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World’s First Bladder Transplant Restores Kidney and Urinary Function in Medical Breakthrough

Performed by USC and UCLA surgeons, the combined kidney and bladder transplant marks a pivotal step in treating terminal bladder disease.

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Overview

  • The groundbreaking surgery, performed on May 4, 2025, at Ronald Reagan UCLA Medical Center, was led by Drs. Inderbir Gill and Nima Nassiri.
  • Oscar Larrainzar, a 41-year-old father of four, regained kidney and bladder function after seven years of dialysis and a nonfunctional bladder due to cancer treatment.
  • The eight-hour procedure involved transplanting a kidney and bladder from the same donor, with immediate restoration of urinary and renal function.
  • This operation is part of a UCLA-led clinical trial aiming to evaluate the safety, feasibility, and long-term outcomes of bladder transplantation.
  • Bladder transplants offer a more physiological alternative to intestinal bladder reconstruction, potentially reducing risks like infections and metabolic imbalances.