U.S. Route 22 (US 22) is a west–east route and is one of the original United States highways of 1926, running from Cincinnati, Ohio, at US 27, US 42, US 127, and US 52 to Newark, New Jersey, at U.S. Route 1/9 in the Newark Airport Interchange. US 22 is named William Penn Highway throughout most of Pennsylvania. In southwest Ohio, it overlaps with State Route 3 and is familiarly known as the 3C Highway, "22 and 3", and Montgomery Road. A section of US 22 in Pennsylvania between New Alexandria at U.S. Route 119 and Harrisburg at Interstate 81 has been designated a part of Corridor M of the Appalachian Development Highway System. From Wikipedia
